Theoretical component: introduction to Tissue Engineering (TE): introduction; history and scope; applications; new perspectives and trends. Fundamentals of TE: biomaterials, cells and signaling; extracellular matrices? structures and functions; cell/biomaterial interactions, cell adhesion; biocompatibility; inflammatory/immune responses. TE scaffolds: chemical, physical and biological properties; delivery of signaling substances; polymeric, inorganic and composite scaffolds: scaffolds fabrication methods and nanotechnologies. TE bioreactors: introduction; cell culture; bioreactors for TE; examples/applications.
Laboratorial component: experimental lab works on different course themes will be performed. Laboratorial demonstrations will be also performed (by teachers and with the help from research students). Experts in several TE areas will be invited to present several specific Seminars.
Bibliography of reference
R. Lanza, R. Langer, J. Vacanti, (Eds), Principles of Tissue Engineering, 3rd Ed, Academic Press, Elsevier, The Netherlands, 2007
J.P. Fisher, A.G. Mikos, J.D. Bronzino, (Eds), Tissue Engineering, CRC Press, Boca Raton, FL, USA, 2007
C.T. Laurencin, L.S. Nair, (Eds), Nanotechnology and Tissue Engineering, CRC Press, Boca Raton, FL, USA, 2008
A. Atala, R. Lanza, J.A. Thomson, R.M. Nerem, (Eds), Principles of Regenerative Medicine, Academic Press, Elsevier, The Netherlands, 2008
R. Barbucci (Ed), Integrated Biomaterials Science, Kluwer Academic Publishers, NY, USA, 2002
B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, (Eds), Biomaterials Science: An Introduction to Materials in Medicine, 2nd Ed, Academic Press, Elsevier, The Netherlands, 2004
J. Park, R.S. Lakes, Biomaterials. An Introduction, 3rd Ed, Springer Science, NY, USA, 2007
Outra bibliografia poderá ser indicada durante as aulas da disciplina/Other bibliographic materials may be provided during course classes.